Advanced Science Journal Cover Design Service (T-ALL)

Advanced Science

06 July 2023

DEX-Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T-Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy

Ruinan Jia^1,†, Tao Sun^2,†, Xin Zhao¹, Guosheng Li^1,2, Yuan Xia¹, Ying Zhou¹, Wˇei Li¹, Wei Li¹, Daoxin Ma^1,2, Jingjing Ye^1,2,*, Min Ji^1,* and Chunyan Ji^1,2,*

10.1002/advs.202370125

In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co-workers observed aberrant adipogenesis in the bone marrow of chemotherapy-treated T-cell acute lymphoblastic leukemia (T-ALL) patients, and the differentiated-adipocytes attract and support residual T-ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect of dexamethason by reducing adipogenesis and provides a feasible strategy to solve the dilemma of recurrence.